Heat helps cancer drugs battle cancer
(PhysOrg.com) -- Localized hyperthermia has been used occasionally with cancer drugs for some time, but until now, the reason it helps has been a mystery. In a report in the Proceedings of the National...
View ArticleDNA repair system affects colon cancer recurrence and survival
Colorectal cancer patients with defects in mismatch repair--one of the body's systems for repairing DNA damage--have lower recurrence rates and better survival rates than patients without such defects,...
View ArticleAging, obsolete cells prime the lungs for pneumonia
Community-acquired pneumonia is the leading cause of infectious death among the elderly. Newly published research from The University of Texas Health Science Center San Antonio suggests why older...
View ArticleAlternative DNA repair mechanism could provide better treatment for...
Researchers at the University of Michigan's C.S. Mott Children's Hospital have identified a promising new target for developing new therapies for kids with high-risk neuroblastoma, according to a new...
View ArticleStudy identifies promising drug target in certain breast and ovarian cancers
The Food and Drug Administration's recent approval of the drug olaparib for ovarian cancer patients with inherited mutations in the genes BRCA1 or BRCA2 came as welcome news to the thousands of women...
View ArticleDNA damage causes immune reaction and inflammation, linked to cancer development
For the first time scientists from Umeå University show the importance of DNA damage in fine tuning of our innate immune system and hence the ability to mount the optimal inflammatory response to...
View ArticleA good night's sleep keeps your stem cells young
In a study just published in the journal Nature, scientists at the Deutsches Krebsforschungszentrum Heidelberg and at the Institute for Stem Cell Technology and Experimental Medicine have uncovered...
View ArticleSunlight continues to damage skin in the dark
Much of the damage that ultraviolet radiation (UV) does to skin occurs hours after sun exposure, a team of Yale-led researchers concluded in a study that was published online Feb. 19 by the journal...
View ArticleDNA safeguard may be key in cancer treatment
Cornell researchers have developed a new technique to understand the actions of key proteins required for cancer cells to proliferate.
View ArticleResearch finds key to gene stability, possible new cancer targets
Researchers in the UC Department of Cancer Biology have found new protein players that help keep genome stability—a promising finding with the potential to help with the development of new targeted...
View Article3-D snapshot of protein highlights potential drug target for breast cancer
The genome of a cell is under constant attack, suffering DNA damage that requires an army of repair mechanisms to keep the cell healthy and alive. Understanding the behavior of the enzymes defending...
View ArticleMechanism by which exposure to vinyl chloride may produce cancerous mutations
In the 1970s, epidemiologists found that workers in factories using vinyl chloride, the key ingredient for PVC plastics, had unusually high rates of a rare form of liver cancer called angiosarcoma.
View ArticleStudy identifies molecular link between DNA damage and premature aging
Like a beloved pair of jeans, human DNA accumulates damage over time, and older people's bodies can't repair it as well. Many scientists believe a build up of damage can cause cells to enter an...
View ArticleStudy may suggest new strategies for myelodysplastic syndromes treatment
A study revealing fresh insight about chromosome "tails" called telomeres may provide scientists with a new way to look at developing treatments or even preventing a group of blood cell disorders known...
View ArticleSmoking induces early signs of cancer in cheek swabs
DNA damage caused by smoking can be detected in cheek swabs, finds research published today in JAMA Oncology. The study provides evidence that smoking induces a general cancer program that is also...
View ArticleScientists reverse aging in human cell lines and give theory of aging a new...
Can the process of aging be delayed or even reversed? Research led by specially appointed Professor Jun-Ichi Hayashi from the University of Tsukuba in Japan has shown that, in human cell lines at...
View ArticleStudy finds gene mutations sensitize tumors to specific cancer drugs
Mutations in ARID1a, which are common in many cancer types, disrupt DNA damage repair in cancer cells, allowing the cancer to progress. This gene may also be an Achilles' heel when treating certain...
View ArticlePneumonia found to harm DNA in lung cells
A bacterium that is the most common cause of pneumonia—a leading cause of death worldwide—can damage DNA in lung cells, a new study has shown.
View ArticleAction spectrum of sun skin damage documented
Scientists document for the first time the DNA damage which can occur to skin across the full range of ultraviolet radiation from the sun.
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